Explainable AI for Diabetic Retinopathy Detection (Boehringer Ingelheim)
Diabetic retinopathy screening needs specialists the world doesn't have enough of. Deep learning can classify retinal images at scale, but in a clinical setting a black-box prediction is unusable: a model nobody can interpret is a model nobody will use.
Started with a SHAP-based interpretability framework for clinical decision support models spanning linear, tree-based and deep architectures, with proof-of-concepts comparing XAI methods against established feature selection and subgroup detection approaches for clinical trials and drug development. My master thesis took it further: deep learning models, including fine-tuned ResNet50, for detecting diabetic retinopathy stages from retinal fundus images, with local colour enhancement and strategic data balancing driving the performance gains. The core of the work was trust: DeepSHAP explanations validated against clinically annotated lesions, so the model's attention could be checked against what ophthalmologists actually look for.